133 Comments

It took me 1,500 hours of reading the past 2.5 years to learn only some of this. I could have just waited for the 30 minute summary 😂 well done. This is such a good summary.

Expand full comment

Excellent account, but I have a serious issue with one point of yours:

" There is absolutely no reason for small children (or, honestly, anyone younger than sixty) to be inoculated against this virus..."

These age qualifications are very dangerous because there is absolutely no reason to give any demographic whatsoever the DEATHVAX. It's like saying, give the oldsters a little cytotoxic endogenous spike protein production a la a little cancer is okay, but neither does anything but kill you over time.

This is a slow kill bioweapon that for far too many subjects turned out to be a relatively fast kill "therapy"

Expand full comment
author
Jul 8, 2022·edited Jul 8, 2022Author

In people over 60, the IFR of the virus may be higher than the lethality of the vaccine (although this is offset by the potential long-term complications from mRNA vaccine induced myocarditis, cancer, autoimmunity, et cetera, which may prove more lethal, eventually). You're right, though. That still doesn't make any of these nucleic acid vaccines an acceptable product. By that, I didn't mean to say that people over 60 should receive an mRNA vaccine. No one should. My point was that the vast majority of people are about as likely to die of COVID-19 as they are of seasonal flu, making a vaccine completely pointless for them.

If an alternative vaccine that lowered mortality in the elderly without causing these severe adverse effects was available, that would be very nice. Unfortunately, SARS has a number of properties that make it practically impossible to safely vaccinate against, not least of which are the potential for ADE and Th2 immunopathology. Those can occur even with a whole-virus vaccine, not just this gene therapy frankengoop they're trying to market and sell as a vaccine.

Expand full comment

VFR (vaccine fatality rate) > IFR (60+ years)

Expand full comment
author

All the information I've seen seems to indicate that the vaccines may have a mortality rate in the area of 0.5 to 2%. Are you saying it's higher? That's extremely shocking and dismaying news, if true. It would mean that there's going to be a great big mountain of corpses.

My father took the vaccine to keep his job. He's over sixty. Sometimes, I like to reassure myself that he didn't sign his own death warrant.

Expand full comment

Slow kill bioweapon.

Lots of death all around, from FIFA to actors to my godmother who had massive heart attack from a single dose to a 36yo member of her church "suddenly" dropping dead while sitting in a chair.

We can finalize that 0.5-2% later, and there is some evidence that various lots are deadlier, etc.

Expand full comment

Pisser does not care about quality control,so obviously there was a difference in the batch lots.It is Russian Roulette....do you feel lucky?

Expand full comment

Highly recommend Hedley Rees extensive Substack on these matters of a total failure of normal manufacturing and distribution procedures. He has interacted with Sasha Latypova and the Bad Batch team to extend understand of their amazing work:

https://hedleyrees.substack.com/

Expand full comment
Jul 8, 2022Liked by Spartacus

Thanks you for your excellent substack.

Your estimate of a 2.2% Covid IFR in my age group was higher than I expected. And maybe I would have been more concerned had I seen that before I contracted it last month. But even so, ever since the Diamond Princess I've told myself that considering the number of obese/unhealthy etc others in any sample group, why the hell would I be the one to die?

Further, even if the so-called vaxx (which I have refused to take) had the same or even lesser mortality risk, there is still a big difference in actively taking on that risk rather than just leaving things to fate. Not to mention standing up for the principle of informed CONSENT.

Expand full comment
Jul 8, 2022Liked by Spartacus

"Covid IFR in my age group was higher than I expected"

Yeah, I wonder where he's getting an IFR of 2.2% for 60 to 69. I don't get that.

Expand full comment

Fatality rates would be for the shorter term.

Now we are seeing new waves of death that are clearly vaccine related but many months and even >1 year in many cases shown in collapses, heart stopping, autoimmune illnesses and fast growing cancers and dementias.

How we put a number on that is best told by insurance company actuaries and funeral directors for now.

The new morbidity in over 60 who were healthy is being revealed in relentless skin conditions, bleeding of the eyes, hastening of the aging process.

We have no basis to argue for vaccines in the elderly to "protect" them now that we have so many safety signals for injury piling in on every sort of illness.

Expand full comment
author
Jul 9, 2022·edited Jul 9, 2022Author

I think people misunderstood what I was trying to say. What I said was that people under 60 have no reason to get it. It was not meant to imply or infer that the reverse (that people over 60 should get it) was true. The mRNA shots must be halted immediately.

Expand full comment

The more boosters the more mortality.

Expand full comment
author

Yep. It's cumulative. Very harmful.

Expand full comment

Dr Shankara Chetty in South Africa, one of the early doctors to develop his own excellent early treatment protocols and a model of the disease is now saying exactly this. He is highly respected in among all the other early treatment physicians and researchers. The vaxxed that refused the boosters can at least feel good about that. This is a good very recent interview; he was able to revive two persons who collapsed on site and then begin to figure out what is causing this and how to see it coming. This is exciting work:

https://www.youtube.com/watch?v=3nPh29eSp28&t=626s

Expand full comment
Jul 8, 2022·edited Jul 8, 2022Liked by Spartacus

Age stratification is key. The IFR for over 70 is 7.5%, so give them the Vax.

But the Vax does nothing to protect against the Virus, nor does it mitigate symptoms or decrease IFR or slow transmission, so don't give it to anyone.

The only real benefits are control and compliance for the government and big profits for pharma, so because of those you might want to Vax everyone including the kids.

Expand full comment
Jul 8, 2022Liked by Spartacus

I love you, Spartacus. I just do. Thank you. Shared and widely!

Expand full comment

Thanks for more fine work, Spartacus.

The spike-protein of the post-Delta variants is much less likely to bind to ACE-2 receptors, binds much better in the upper airways, causes much less endothelial dysfunction and inflammation, and therefore less COVID-pneumonia, which, as you state, is a different kind of "pneumonia".

This greatly lowers the lethality of current strains, though they are also even more infectious, even to those who have had COVID, but especially to the "vaccinated", who seem to get antibody-dependent-enhancement of viral pathogenicity, a trend already apparent in the over-60 (first-vaccinated) group in the UK a year ago.

It is very hard to keep up with mutations, but the first Omicron variant did not appear to be a natural mutation from any known circulating variant which had preceded it. It also, by default, seems to have been a lab-creation. To what end? It did give COVID another round of "legs", especially in the "vaccinated", but it is slightly less lethal than the average seasonal influenza now, and subsequent B.A.5 and others , which may be even more infectious, don't appear to be very lethal.

It seems that governments seek to use "spread of COVID" as a justification for emergency measures, even as most people who are paying attention have lost their fear of it, and are deciding that they are done with getting vaccinations, declining boosters. It's not very scary, even if you are not paying close attention, and word is out about the mysterious excess-deaths not-from-COVID.

Keeping your vitamin-D level in the mid-normal range, being active daily and eating fresh vegetables cooked and raw as the basis of one's diet are all good.

OTC Rxs for Omicron is a post I put up just before I caught Delta for New Years. It is still immediately useful. https://www.johndayblog.com/2021/12/otc-covid-rxs-for-omicron.html

(It's on my pre-substack blog, that started getting censored in February of this year, when I started posting about the Ukraine war.)

Expand full comment
Jul 8, 2022Liked by Spartacus

Beets are rich in nitrates which are readily converted into nitrous oxide. It’s an excellent and natural way to lower blood pressure and keep a healthy amount of NO in circulation. I don’t jog, but I go for a brisk 4 mile walk every morning, and I always have a tall glass of beet juice before I leave.

Expand full comment
Jul 9, 2022Liked by Spartacus

Drug Discovery you are my "morning routine" twin soul mate.

Expand full comment
Jul 9, 2022Liked by Spartacus

...and now you’re gonna tell me your walking companion is a border collie, right?!😎

Expand full comment
Jul 9, 2022·edited Jul 9, 2022Liked by Spartacus

Kelpie Blue 3 legs dog. Quite a ladies man in his prime, nothing could stop him, not a fence, not a car...until it did. The most spiritual, emotionally intelligent dog that reads me like a book...quitely determined he has his way with me. And i like it eventhough I pretend I dont ,( sometimes) just for "sweet love fightings of wills). Off to juice my beets & walk 😎

Expand full comment
Jul 9, 2022Liked by Spartacus

My dog chases trains, boats, motorcycles and anything with a trailer... so, very limited and highly supervised off-leash time. The trail I go to is off-leash, but runs beside train tracks, and the 20 feet space between the trail and the tracks is lined with trees and shrubs, so we don’t really see the trains, but we hear them. I developed a very fine tuned ear for distant train rumblings!

Expand full comment
deletedJul 9, 2022·edited Jul 10, 2022
Comment deleted
Expand full comment

Sorry Bibi, there's nothing romantic in here: I just wanna make sure the dog gets back home in one piece and I don't blow the dog's health care budget. Lunatics are all around, so I would highly recommend you to exercise the 2nd and get some weapons training. And juice those beets!!!

Expand full comment

I also had Covid around the same time as you. Very mildly but also had mild brain fog (as you mentioned above) for a few days. Do you have more information on this? Alzheimer's like inflammation doesn't sound great! Any concerns if it went away quickly? Any supplements which should be taken?

Expand full comment
author
Jul 8, 2022·edited Jul 8, 2022Author

Persistent COVID-19 brain fog is physiologically very similar to Alzheimer's, in that there is immune activation in the brain, iron dysmetabolism, calcium overload, lipid peroxidation, microvascular injury, tauopathies/amyloid buildup, et cetera. If it resolved, I wouldn't worry about it too much.

https://www.medpagetoday.com/neurology/generalneurology/97034

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12558

https://alzres.biomedcentral.com/articles/10.1186/s13195-021-00850-3

I'd try curcumin, quercetin, melatonin, and nattokinase (or serrapeptase), and maybe kutki powder. These have an anti-inflammatory, antioxidant, anti-amyloid effect.

Expand full comment

Could Spartacus and the Emperor comment on minocycline and low dose naltrexone? Both have anti-inflammatory effects, particularly in the brain, popular in autoimmune diseases and used effectively in the tickborne illness cohort. LDN acts on TLR4, as does minocycline. Minocycline unlike the tetracyclines are lipophilic so are good for neural and brain inflammation, and both are microglial anti-inflammatories.

Also Metformin as it acts on those pathways you discuss and general metabolic health.

A quick search of PubMed will reveal utility for all these compounds in C19 directly.

The post COVID and post vax protocols will grow in a big way over time. And those protocols will overlap and merge with general protocols for anti-aging and metabolic health. Again more safe and repurposed meds in addition to neutraceuticals to manage chronic health. Like the old fashioned concept of a daily tonic for health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7705311/

Thank you for all you do and your efforts early on. Many more of these stories will be forthcoming about how help was offered and rebuffed. America is an all hands on deck kind of culture in an emergency, so none of this government response was natural. That was traumatic and we will have to be recover from that, being told to stand down, while people were harmed and murdered.

Expand full comment
author

Anything that reduces TNF-α and IL-6 secretion will help. Minocycline does that. Naltrexone reduces TNF-α and IL-10, but may increase IL-6.

SARS-CoV-2's E and 3a proteins act like calcium ion channels, its Orf3 directly activates the NLRP3 inflammasome, its main protease may cleave and destroy GPX enzymes, and the Spike protein may bind TLR4, and Neuropilin-1, and may also bind bacterial LPS. As the virus infects the vasculature, it promotes a sort of sepsis-like syndrome that leads to severe inflammation and rapid endothelial degradation. The calcium overload causes mitochondrial stress and dysfunction, leading to fatigue, while also promoting viral replication. SARS-CoV-2 infected cells readily form syncytia with adjacent cells. There are modifications to autophagy, likely to preserve the DMVs the virus makes inside cells to act as virus factories.

Generally, when I think of ways to treat COVID-19, what I think about is enhancing endogenous antioxidant activity (NAC, glycine, selenium, and so on), direct antioxidant therapy (apocynin, curcumin, resveratrol, famotidine, diphenhydramine, fluvoxamine), blocking and removing excess calcium from cells (Vitamin D, amlodipine), preventing the breakdown of hypoxanthine into superoxide (allopurinol), iron chelation (deferoxamine), bradykinin modulation (methylene blue), et cetera. I go into some of this at the end of the first Deep Dive article:

https://iceni.substack.com/p/covid-19-deep-dive-part-i-pathophysiology

Instead of doing that, people were put on ventilators (makes more oxygen radicals) and given steroids (oxygen radicals make glucocorticoid receptors insensitive to steroids), so they end up with inflammatory rebound and even more catastrophic lipid peroxidation in the lung parenchyma. The desaturation is a serious problem, and these people turning blue in the face often do need oxygen immediately to survive, but it's a double-edged sword. It would be much better to try NIV first and then go in with a therapeutic cocktail. Not to mention, early outpatient treatment instead of brushing people off and having them come back even sicker (at which point a lot of therapeutic approaches would fail simply due to the time-sensitive nature of treating sepsis).

The neutrophilia of COVID-19 is devastating:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757048/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488868/

https://www.nature.com/articles/s42003-021-01829-4

I've been begging people I know (who are involved in COVID patho research and healthcare) to look into apocynin for the past two years:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525285/

Expand full comment
Jul 9, 2022Liked by Spartacus

Spartacus, hyphothetically, if someone was to leave their estate , inheritance etc after their death to "people" who could do the reserch you mention above , what would be the best way to do it?

Expand full comment
author

That's a good question. I'm sure there are charitable foundations out there that are doing the relevant work, but there is also a lot of profiteering in pharma, unfortunately. They want to give everyone a pill for everything. Obesity pills, depression pills, erection pills, hair pills, et cetera, et cetera. The research they support tends to run along those lines; looking for patentable, marketable synthetic substances that act as ligands for human receptors. There's very little focus on holistic wellness. They don't profit from that. They profit from people being chronically ill and then chugging pills to get rid of the symptoms. Unfortunately, a lot of fundamental research goes into supporting this cycle, because grant money and venture capital goes towards products with a guaranteed financial return. Hence, a system has been created that profits from the ruination of our health and the perpetuation of human misery. Don't get me wrong; some good, lifesaving pharmaceuticals have come out of this sort of work, but also, a lot of duds, or worse. My father was prescribed Levaquin after a nasal polyp removal surgery to unblock his sinuses. It gave him lasting tendinitis and neuropathy in his feet. He has so little feeling in his feet, now, he loses his balance, stubs his toes and trips over things. I'm sick to death of seeing people harmed by "medicine" that isn't.

Expand full comment
Jul 9, 2022Liked by Spartacus

I did my own research and I agre with everything you said. On one hand it seems I am naive, looking for something that does not exist, yet. On the other, reading your post and Arkmedic, Jikky, Walter's, Igor's I feel so trustworthy and excited that people like you still exist. If innovation, honor and carring still exist, and substacks I mentioned prove that they do, then they can be replicated elsewhere..its basic system theory. Have you thought of what success would look like if you were to succeed in creating the wholistic driven Pharma /Medicine that is in Person"s intrest Person Centric Approach Medicine% Research? If not, think about it. If you wish. Thank you for all the articles, replies, everything you have done and continue to do. Your articles are touching on so many levels. ❤🙏❤

Expand full comment

💜

Expand full comment

Do indepth research on Metformin, while it is one of the most widely prescribed drugs around, they are many studies correlating it to dementia and other issues.

Expand full comment
Jul 8, 2022Liked by Spartacus

Great substack. The absolute GEM of substack. It is so refreshing to hear such a well rounded insight into all "things" covid. So grounded and courageous. Deep unadulterated respect and admiration.

I hate having to say this and with deep sadness I feel I have to, when something is "physiologically very similar to Alzheimer's" ...that "something" is progressive. Regardless of protocols you mention here or more widely used therapeutics.

Expand full comment

Hi. I am 68, immunocompromised (rheumatoid arthritis), unvaxxed and surrounded by Covid sufferers. Got a slightly scratchy throat but otherwise fine. I take NAC, vitamin D, zinc, vitamin C and black seed oil

Expand full comment
Jul 9, 2022·edited Jul 9, 2022Liked by Spartacus

Also, every Twitter post conveying the obvious (to scientists) link between prion pathways (Alzheimer's like inflammation) was deleted, accounts susspended etc EVERY TIME see @ichudov & Walter's wmc research. EVERY TIME those are the tweets that get them suspended. Why would Twitter care ? They were not promoting snake oil. There was no "disinformation ' . They were stating the scientifically based possibility. Why is Twitter so concerned about anyone discussing any possibility about anything? If you committed the murder by using tomatoe and get away with it, how would you feel if a year later, you are at the party and suddenly somebody mentions tomato as a possible perfect murder bioweapon?

Expand full comment
Jul 9, 2022Liked by Spartacus

The Sunday before last Pfizer ran a full-page ad in the South Florida Sun Sentinel detailing the signs of ATTR-CM (transthyretin amyloid cardiomyopathy). ConnectHeartFailure.com. They want you to ask your cardiologist about it. The same ad also appeared in the Parade Magazine supplement. Another breakthrough medication?

Expand full comment

In Australia it hasnt been mentioned yet. I do not know. Have no opinion, yet. Thank you for making us aware about it.

Expand full comment

Keep us posted when you find out more about it🙏❤

Expand full comment
Jul 9, 2022·edited Jul 9, 2022Liked by Spartacus

You can easily and quickly fix rheumatoid arthritis if you stop eating plants (so animal-based only). Plant defense chemicals essentially cause all autoimmune diseases. Try it and see for yourself.

https://www.youtube.com/watch?v=MeXZ-MsFNkY

Expand full comment

Thanks, yes it resolved pretty quickly and wasn't that bad at all, I just knew something was different. I wondered at the time how it managed to get into the brain and whether that meant anything long term.

Expand full comment
author

They've known that SARS was neuroinvasive for a long time:

https://academic.oup.com/cid/article/41/8/1089/377612

COVID-19 is similar:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9146514/

Expand full comment

Thank u for that Spartacus

Expand full comment

Antioxidants and foods with similar properties.

Expand full comment

Nrf2 for the win - and by the way, pomegranate peel acts as a fusion inhibitor too.

Nrf2 and NF-kB - two proteins to know. https://denutrients.substack.com/p/nrf2-and-nf-kb-2-proteins-to-know?r=os7nw&s=w&utm_campaign=post&utm_medium=web

Expand full comment
Jul 9, 2022·edited Jul 9, 2022Liked by Spartacus

Spartacus, I lost trust in my GP (Australia/Canberra) I would like to find a wholistic, well informed (as per your articles and other substack illuminaries Arkemdic, Jikky, Walter, Igor) , uncorrupted GP anywhere in the world who does Tele health for Australians. Is there anyone you could recommend? Thanks

Expand full comment
author

Don't know anyone, sorry. I'm in the same boat as you are, on that. :(

Expand full comment

Dr Kory Spartacus

Expand full comment

Bibi, you can contact Dr Kory thru his website . He has a substack and I believe he will answer you!!

Expand full comment
Jul 10, 2022Liked by Spartacus

Brandon thank you! Grateful for your reply. I thought as Australian I would need a GP licensed for Australia. I am in no hurry, but if I ever get C19 I would like to know whom to call (so I dont have to call Ghost Busters). Have you heard about the Povidone Iodine nasal spray? If so how can we make it?

Expand full comment

Bibi… Dr. McCullough has a web site. Nasal concentrations up to 1.25% and mouth up to 2.5% up to 5 months. It inactivates coronavirus in 15 seconds. I use a q tip dip in providing -iodine. In my nose periodically.

Expand full comment
Jul 8, 2022Liked by Spartacus

More brilliant work. Thanks.

Expand full comment

It's Hopium to think that anyone responsible will ever be held to account. All revolutions require elite backing and all elites have been captured. All has always been Lost. Simply look to the Results to see it.

Ashes and Echoes

Expand full comment

Not to change the subject and maybe I’m not posting in the right place…. But I work in a delivery ward and there is such a weird increase in cloacal anomalies / genitourinary defects in newborns in vaccinated mothers . That’s beside the abruptions and preterm deliveries. Any thoughts if you or anyone has an embryology background?

Expand full comment
author
Jul 9, 2022·edited Jul 9, 2022Author

I've heard rumors (nothing confirmed, though) of possible germline alterations from the vaccine transfecting germ cells, leading to consistent patterns of birth defects. This needs a lot more follow-up.

The nucleic acid vaccines were not supposed to alter DNA, but they might be doing exactly that. People have been hoodwinked into thinking that messenger RNA can't be turned back into DNA, when endogenous reverse transcriptases like LINE-1 are capable of exactly that.

Expand full comment

Has that been born out in humans or just in the lab cultures? Thanks so much for your work. I have been tirelessly reading and researching all these post 2019 years and yours is a prominent voice in this guy's 'Hero's Journey' - you are such great company and a true brother in spirit.

Expand full comment
author

You're most welcome. :)

I believe this has only really been detected in vitro, under somewhat artificial conditions. However, it does outline a possibility that requires further examination. In short, the risk of DNA modification that they say is zero is actually non-zero.

Expand full comment

Stephanie Seneff, Peter McCullough and Jessica Rose who talk about a paper and other evidence that showed this was happening I believe.

Expand full comment

I finally got the Pediatrician to admit to anomalies. I said “don’t you see any trending?”. Trending is critical then comes the data and what to investigate.! I got her to admit to cloacal defects , genitourinary urinary defects and preterm deliveries and stillborns. But no data yet she said !! I said …. TRENDING is critical first step with new drugs…🥲

Expand full comment
Jul 15, 2022·edited Jul 15, 2022Liked by Spartacus

If the vaccine affects LINE-1 expression, this would theoretically in turn affect DNA methylation. When DNA methylation is altered it affects embryogenesis and fetal development. One of the major types of fetal deformities that can result from disrupted DNA methylation is midline defects: things like genitourinary defects. Boom, there's your mechanism.

Expand full comment

Dear NoraS thank you!

Expand full comment
Jul 15, 2022Liked by Spartacus

Some background on what we're dealing with re LINE-1 reverse transcription activity: https://palexander.substack.com/p/lasting-legacy-of-trojan-horses-an

That article presents an anonymous post on 4chan in Dec. 2020 from two people who claimed they were engineers at Moderna. These engineers claimed that something was put in the Covid mRNA vaccines which upregulates LINE-1.

Based on what you are seeing in your delivery hospital, the mechanism I suggested, and what we may be seeing with fertility rates in highly vaccinated countries, this 4chan post is starting to look real, isn't it? It also fits with what Spartacus says about this whole Covid emergency having been planned.

We in Western democracies are no longer represented by real people; we are ruled by demons.

Expand full comment

That’s part of the insertion of pseudouridine ? That was the key to me that it’s a bio weapon. Thanks for responding, I love the science behind this and trying to wrap my head around the demons who created it .

Expand full comment
author
Jul 16, 2022·edited Jul 16, 2022Author

The pseudouridylyl was used in place of uridine in the mRNA sequence. This was apparently to reduce its immunogenicity. It's based on Katalin Karikó's work, which showed reduced TLR activation by modified RNA:

https://www.cell.com/immunity/fulltext/S1074-7613(05)00211-6

With the codon optimizations and other properties of this mRNA, it's unlikely that it's translating into anything even slightly Spike-protein shaped, conformationally. Also, the consistency of the translated proteins may be very poor. I've also seen a preprint that suggests that the Pfizer vaccine actually reduces the sensitivity of TLRs to anything that would normally bind and activate them.

Expand full comment

Spartacus thank you!! I really enjoy being educated on the inner workings of Covid !!😀🌸

Expand full comment
Jul 9, 2022Liked by Spartacus

Any thoughts on MCC950?

Walter M Chesnut: "OF BATS, CORONAVIRUSES AND EXTREME HUMAN (INFLAMM)AGING: WHY BAT CORONAVIRUSES ARE HUMAN NEUTRON BOMBS: MCC950 TO THE RESCUE

Depopulation and GOF Research: Is MCC950 Our Savior?

Expand full comment
author

It's a selective inhibitor of the NLRP3 inflammasome:

https://www.nature.com/articles/s41598-018-26775-w

SARS-like coronaviruses directly activate the NLRP3 inflammasome:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762580/

It's a very reasonable drug target.

Expand full comment

Numerous published papers on neutraceuticals, probiotics, exercise for NLRP3 inflammasome, long recognized in other chronic inflammatory illness conditions as helpful if not essential components of recovery and management protocols. You can spend hours poring through papers on this topic in PubMed. Of course just before the pandemic the ketogenic, low carb, high nutrient, paleo food movements were maturing and gaining really good traction, as well as those experts who caught the same kind of relentless pushback from Big Food and Conventional Nutrition that the COVID19 frontline docs and researchers are receiving.

https://pubmed.ncbi.nlm.nih.gov/33375692/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840562/

Bruce Patterson and Ram Yogendra have been using Maraviroc in their long COVID protocols, although front line doctors are quietly saying you don't need to go there to cover NLRP3 issues until it is better studied. Patterson bought the patent then is publishing and presenting on this, so always be skeptical of conflicts of interest and the power of money. They do also publish on a set of well validated biomarkers for long COVID, most of which can be targeted by more time tested and even non pharmaceutical means. However, more papers are coming out by separate groups on Maraviroc:

https://pubmed.ncbi.nlm.nih.gov/35799534/

Expand full comment
author
Jul 9, 2022·edited Jul 9, 2022Author

Persistent immune activation + amyloidosis/proteopathy (like Walter Chesnut has been saying) = Long COVID/PASC. The brain fog is persistent CD8+ T cell angiopathy and microglial activation, with possible aggravation by tauopathies promoted by the virus's own proteins.

https://www.science.org/doi/pdf/10.1126/science.abm2052

It resembles the persistent immune activation in the brain that people experience after chemotherapy, in fact.

https://www.cell.com/cell/fulltext/S0092-8674(22)00713-9

SARS-CoV-2's proteins are indeed highly amyloidogenic:

https://pubs.acs.org/doi/10.1021/jacs.2c03925

https://pubs.acs.org/doi/10.1021/acschemneuro.1c00666

Basically, we're looking at the possibility of persistent immune activation due to persistent proteopathy long after the virus clears from the body. The immune system may be lightly suppressed to get rid of the symptoms, but that leaves the question of what to do about the amyloid. Target with mAbs, maybe?

The mention of Maraviroc is interesting, given COVID-19's known interactions with CCR5:

https://www.sciencedirect.com/science/article/pii/S1201971220323055

https://www.immunology.ox.ac.uk/covid-19/covid-19-immunology-literature-reviews/disruption-of-the-ccl5-rantes-ccr5-pathway-restores-immune-homeostasis-and-reduces-plasma-viral-load-in-critical-covid-19

Expand full comment
Jul 8, 2022Liked by Spartacus

I am Spartacus! ✊🏻

Expand full comment
Jul 9, 2022Liked by Spartacus

no I am Spartacus

Expand full comment

#metoo

Expand full comment
Jul 9, 2022Liked by Spartacus

😉✊🏻👍🏻🙏🏻

Expand full comment
Jul 8, 2022Liked by Spartacus

This is gold.

Expand full comment

Also, do you have more detailed explanation of the link between hydroxyl radicals and the autoantibody formation? As a physician, I have seen anti phospholipid Ab many times before.....but this is a new link for me. A few papers would be nice to explain it in more detail since I am not getting it.

Expand full comment
author
Jul 8, 2022·edited Jul 8, 2022Author

It's lipid peroxidation and oxidation-specific epitope formation in general:

https://ashpublications.org/blood/article/90/10/3931/139483/Enhanced-Lipid-Peroxidation-in-Patients-Positive

https://www.nature.com/articles/nri.2016.63

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844667/

https://www.liebertpub.com/doi/10.1089/ars.2021.0017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757048/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334659/

It's similar to lupus. In SLE, people end up with neutrophils going haywire, just like COVID-19, but in the skin and joints instead of the vascular endothelium. The damaging enzymes in the NETs are the problem. The oxidatively-modified lipids are viewed by the immune system as non-self. Foreign objects, essentially. Autoantibody formation is inevitable when that happens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108063/

COVID-19, like lupus and rheumatoid arthritis, is "granulocyte hell", but in the blood vessels.

Expand full comment

Ha! I asked for articles. Thank you. Will read. Granulocyte hell describes bacterial sepsis too. "oxidatively-modified lipids" .... that makes some sense. Like margarine, but H not O. Margarine = bad!

This may be way off (cuz I haven't read articles yet), but I was looking at this last week. Seems to help with long covid.

https://beatejaeger.com/en/h-e-l-p-apheresis/

Expand full comment
Jul 8, 2022Liked by Spartacus

Dear Betsy Alzheimer's a progressive disease. As such it is terminal. Some protocols might slow the progression but nothing will stop or cure it. If COVID is " inflammatory like Alzheimer'" it means it is progressive. Terminal.

Expand full comment