Mechanisms of COVID-19 Vaccine Injury

Vaccines are not magic; they are chemical substances, and therefore open to analysis

A Harmful Vaccine

Evidence of the injurious potential of the vaccines continues to pile up. I figured it was a good time to summarize what we know thus far about all of this.

There are numerous COVID-19 vaccines of various types. These are some of the ones currently in use or in development:

• mRNA

  • Moderna mRNA-1273/Spikevax

  • Pfizer-BioNTech BNT162b2/Comirnaty

• Adenovirus Vector

  • Oxford-AstraZeneca AZD1222/Covishield/Vaxzevria

  • Gamaleya Sputnik V/Gam-COVID-Vac

  • CanSino AD5-nCOV/Convidecia/PakVac

  • J&J/Janssen Ad26.COV2.S/Jcovden

• Protein Subunit

  • Novavax NVX-CoV2373/Nuvaxovid/Covovax

  • VECTOR EpiVacCorona/Aurora-CoV

  • Anhui Zhifei Longcom ZF2001/Zifivax

  • Medigen MVC-COV1901

  • Texas Children’s Hospital/Baylor College Corbevax/BECOV2D

• Inactivated Virus

  • Sinovac CoronaVac/PiCoVacc

  • Sinopharm BIBP/BBIBP-CorV

  • Sinopharm WIBP/WIBP-CorV

  • Bharat Biotech BBV152/Covaxin

  • Chumakov Centre CoviVac

In the US, the majority of vaccines administered have been of the mRNA type. As of May 15th, 2022, this number stood at 343,060,118 doses of the Pfizer-BioNTech vaccine, 219,297,720 doses of the Moderna vaccine, 18,746,828 doses of the J&J/Janssen vaccine, and 566,172 doses of all others.

Number of COVID-19 vaccine doses administered in the United States as of May 15, 2022, by vaccine manufacturer

The mRNA vaccines for COVID-19 were the first of their kind. These vaccines were developed largely with funding from the US biodefense network, particularly DARPA and BARDA funding for Moderna, and were originally considered in the early 2010s as a means of swiftly inoculating soldiers against pandemic pathogens or, presumably, against bioweapons.

How the U.S. government bolstered Moderna’s COVID-19 vaccine candidate

The National Institute of Allergy and Infectious Diseases (NIAID) developed a stabilized SARS-CoV-2 spike immunogen (S-2P) that Moderna would later use in its messenger RNA platform.

DARPA was instrumental in the development of RNA vaccines and provided $25 million in financial support to Moderna in 2013 to pursue messenger RNA–based antibody drugs and vaccines. DARPA announced it was committing up to $56 million in additional funding to Moderna this October.

BARDA has committed another roughly $955 million to Moderna.

In Moderna’s case, mRNA-1273/Spikevax is their first-ever commercial pharmaceutical product.

These vaccines underwent highly accelerated trials.

Accelerating vaccine trials - WHO

Typically split into three phases (although a zero phase is sometimes added), clinical trials comprise a small trial to test safety, followed by a larger trial to test immune response at different doses to select the optimal dose and continue identifying side-effects, and finally a much larger clinical trial to establish efficacy, i.e. whether or not the vaccine actually protects against infection and/or disease.

In the face of the COVID-19 pandemic, and under tremendous pressure from governments worldwide, vaccine developers have had to squeeze these steps into months rather than years.

The clinical trials of the Pfizer/BioNTech vaccine trial took eight months. Trials of the Moderna and AstraZeneca vaccines, the other COVID-19 candidate vaccines approved for use in 2020, were conducted with similar alacrity.

Because these trials used highly compressed phases, there is no possibility for them to have detected long-term side effects from the vaccine.

There have been many discrepancies with these trials, as well. A whistleblower at the subcontractor Ventavia claimed Pfizer’s trial data was falsified:

Company That Managed Pfizer Vaccine Trial Sites ‘Falsified Data’: Whistleblower

A researcher who was employed by a company that oversaw three clinical trial sites of Pfizer’s COVID-19 vaccine has made shocking revelations about poor practices at the facilities that call the integrity of Pfizer’s data into question and also raise concerns about lax regulatory oversight.

Curiously, the media report has been seized upon by multiple outlets of the Russian media, including the Russian news agency TASS and the Twitter account for the Sputnik vaccine.

Brook Jackson, a regional director who was employed by Ventavia Research Group, told British Medical Journal that the company “falsified data, unblinded patients, employed inadequately trained vaccinators, and was slow to follow up on adverse events” reported in the pivotal phase III trial of the Pfizer-BioNTech vaccine.

Pfizer have been legally compelled to release their data, and these documents have revealed many alarming discrepancies, as well:

Pfizer’s Clinical Trial Data Is a Mystery

While recruiting for Site 1231, Dr. Polack also:
1. Was an Adjunct Professor in the Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University.

2. Appeared on behalf of the FDA, for whom he has been a consultant since 2017.

3. Worked for The Infant Foundation, which is funded by the Bill & Melinda Gates Foundation and the NIH.

4. Was the lead author of “Safety and Efficacy of the BNT163b2 mRNA Covid-19 Vaccine,” published in the New England Journal of Medicine online on Dec. 10, 2020.

Each of his 4500 recruits requires 250 pages of case report forms. That means Dr. Polack filled out 1,125,000 pages of CRFs, in three weeks, by himself. This creates another puzzler.

This is brand-new technology, tested under a highly accelerated schedule and with a suspicious methodology, and in Moderna’s case, from a company with no prior commercial products, that received most of their funding for their mRNA vaccine research from Pentagon think tanks.

It is absolute insanity to mandate these products be administered to people, on pain of job loss, movement restriction, loss of access to services, et cetera.

The mRNA vaccines are categorized as nucleic acid vaccines, because they consist of synthetically-capped, pseudouridylated messenger RNA encapsulated in lipid nanoparticles. This mRNA codes for a proline-substituted, prefusion conformation locked version of SARS-CoV-2 Spike, such as 2P Spike. To produce Spike proteins inside the body, the lipid nanoparticles are endocytosed into deltoid muscle cells, transfecting the mRNA into those cells and causing their ribosomes to translate the mRNA into Spike proteins. Those Spike proteins then migrate to the surfaces of those cells and become membrane-bound proteins, protruding from the cell wall much as they would protrude from the surface of SARS-CoV-2 if assembled onto a virus by its replication processes. The immune system then recognizes them as an antigen and forms antibodies against them. That’s how it’s all supposed to work, in theory.

These vaccines quite literally use human cells as bioreactors to produce viral proteins. The same thing could conceivably be done outside the body. Genetic material coding for Spike could be introduced to E. Coli bacteria or yeasts, cultivated, and the protein collected and purified, just like how subunit vaccines, recombinant insulin, or other biologics are made.

Nucleic acid vaccines are a shortcut. They are protein subunit vaccines where you are the bioreactor, and your own cells make the protein of interest instead of E. Coli in a vat.

This method raises a number of questions.

1. Are the PEGylated lipid nanoparticles safe and non-toxic and do they remain solely at the injection site?

2. Is synthetically-capped, pseudouridylated mRNA safe to have inside the human body?

3. Is SARS-CoV-2 Spike a safe vaccine antigen?

As far as we can tell, the answer to all of these questions is a resounding no.

A Laundry List of Issues

• Lipid Nanoparticles

  • Toxicity of LNPs

    • Safe Nanoparticles: Are We There Yet? - MDPI

    • Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review - STAM

  • Allergic Reactions

    • Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines - Elsevier Molecular Therapy

  • Biodistribution

    • Pfizer Biodistribution Study - Acuitas Therapeutics

    • In vivo fate and intracellular trafficking of vaccine delivery systems - Elsevier

• Synthetic mRNA

  • Nuclease Resistance/Stability

    • The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines - Frontiers

    • From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape - Frontiers

  • TLR Interference/Immune Suppression

    • Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

    • The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses - medRxiv (Preprint)

  • Stop Codon Readthrough

    • Therapeutics Based on Stop Codon Readthrough - Annual Reviews

    • Pseudouridine-mediated stop codon readthrough in S. cerevisiae is sequence context–independent - RNA

    • Transcriptome-wide dynamics of RNA pseudouridylation - HHS Public Access

  • Possible Mitochondrial Deafness or Autoimmune Attack on Auditory System

    • Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening - Elsevier

    • Mitochondrial mutations in maternally inherited hearing loss

    • Sudden sensorineural hearing loss after COVID-19 vaccination

  • DNA Repair Inhibition

    • SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro - MDPI

      • This article was retracted due to flaws in experimental methodology. We would like to see the matter reexamined with better-designed experiments.

  • LINE-1 Reverse Transcription

    • SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome - bioRxiv (Preprint)

      • This was after infection, not vaccination, and it was in vitro.

    • Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line - MDPI

      • Comment on Aldén et al. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. Curr. Issues Mol. Biol. 2022, 44, 1115–1126 - MDPI

• Spike Proteins

  • Poor Antibody Responses

    • Boosting of Cross-Reactive Antibodies to Endemic Coronaviruses by SARS-CoV-2 Infection but not Vaccination with Stabilized Spike - medRxiv (Preprint)

    • Anti-nucleocapsid antibodies following SARS-CoV-2 infection in the blinded phase of the mRNA-1273 Covid-19 vaccine efficacy clinical trial - medRxiv (Preprint)

  • Cleavage and Presence in Bloodstream

    • Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients - Clinical Infectious Diseases

  • Spike Effects on ACE2

    • SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 - AHA Journals

    • Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor - ACS

    • The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition - Elsevier

  • Coagulopathy

    • Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine–Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis - JAMA

    • Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways - MDPI

    • A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications - Portland Press Biochem Journal

    • Evidence of SARS-CoV-2 Spike protein on retrieved thrombi from COVID-19 patients - Research Square (Preprint)

    • Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots - BMJ

  • Superantigenic Properties

    • Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation - PNAS

    • Super(antigen) target for SARS-CoV-2 - Nature

  • Amyloidogenesis

    • SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration - Elsevier

    • Amyloidogenesis of SARS-CoV-2 Spike Protein - ACS

  • Autoimmune Attack

    • Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model - Clinical Infectious Diseases

    • Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID-19 and the need for biodistribution evaluations - Wiley

    • New-onset autoimmune phenomena post-COVID-19 vaccination - Wiley

    • Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs - Elsevier

    • Auto-immune hepatitis following COVID vaccination - Elsevier

    • Autoimmune hepatitis after COVID-19 vaccine – more than a coincidence - Elsevier

    • SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis - Journal of Hepatology

    • COVID‐19 vaccine causing Guillain‐Barre syndrome, a rare potential side effect - Wiley

    • Covid-19 vaccine and autoimmunity: Awakening the sleeping dragon - Elsevier

  • Integrin Binding

    • A potential role for integrins in host cell entry by SARS-CoV-2 - Elsevier

    • Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 - JBC

    • ACE2-independent infection of T lymphocytes by SARS-CoV-2 - Signal Transduction and Targeted Therapy

  • LPS Binding

    • SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity

    • SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

  • Blood Brain Barrier Effects

    • SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation - Springer

    • The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier - Elsevier

    • The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice - Nature

Consequences

From the available data, our conclusions regarding the mRNA vaccines are as follows:

1. The PEGylated LNPs are capable of occasionally causing severe allergic reactions. The LNPs do not remain at the injection site, but travel all over the body and accumulate in key organs.

   1. Unlike the virus, which only infects cells that express the host factors, LNPs can be endocytosed by practically any cell.

2. Synthetically-capped, pseudouridylated mRNA:

   1. Resists breakdown by nucleases and may accumulate and persist over a long period of time.

   2. May act as a TLR7/8 inhibitor.

   3. May encourage stop codon readthrough and translate normally untranslated regions of the mRNA strand, resulting in an unknown product with unknown properties.

      1. Pfizer’s vaccine, which contains mtRNR1 in its UTR, may promote mitochondrial toxicity and mitochondrial deafness if this UTR is translated, though this has never been confirmed.

   4. May be taken up by LINE-1 retrotransposon activity and reverse-transcribed into DNA.

      1. If this DNA expresses Spike, then the afflicted cell may express Spike continuously.

3. SARS-CoV-2 Spike produced by the vaccine can be cleaved by endogenous proteases, resulting in loose S1 entering the bloodstream.

   1. This implies that proline substitution does not render the Spike inert.

4. SARS-CoV-2 Spike is:

   1. Incredibly pro-coagulant and harmful to endothelial integrity.

   2. Highly inflammatory, with a Superantigenic region.

   3. Capable of penetrating the blood-brain barrier.

   4. Has a heparin-binding domain, is amyloidogenic, and can aggregate Aβ, α-synuclein, tau, prion, and TDP-43 RRM, potentially generating amyloid fibrils and plaques as well as Lewy bodies. In the bloodstream, it may also generate amyloid fibrin clots.

   5. Can potentially bind to LFA-1 Integrins in an ACE2-independent manner, much like HIV gp120.

   6. Can potentially bind and aggregate bacterial lipopolysaccharides and enhance endotoxin activity.

5. The expression of Spike by healthy cells may provoke autoimmune attack. Any cell that expresses SARS-CoV-2 Spike after being transfected with mRNA may be destroyed by the immune system.

   1. Inadvertent intravenous injection is very harmful and can cause myocarditis and profound heart scarring.

   2. The vaccines may trigger autoimmune attacks on nervous tissue, leading to Bell’s Palsy or Guillain-Barré.

   3. The vaccines may trigger autoimmune hepatitis.

   4. The vaccines may affect fertility or fetus viability if they trigger autoimmune attack against germ cells or fetal tissues.

Can vaccine injuries be proven? Yes. Through the DMED and VAERS, as well as life insurance data.

Renz Whistleblowers DMED DATA Reveals Incredibly Disturbing Spikes in Vaccine Injuries Across the Board

279% SPIKE in Miscarriages
487% SPIKE in Breast Cancer
1048% SPIKE in the Nervous System
155% SPIKE in Birth Defects
350% SPIKE in Male Infertility
369% SPIKE in Testicular Cancer
2181% SPIKE in Hypertension
664% SPIKE in Malignant Neoplasms
680% SPIKE in Multiple Sclerosis
551% SPIKE in Guillain-Barre Syndrome
468% SPIKE in Pulmonary Embolism
302% SPIKE in Tachycardia
452% SPIKE in Migraines
471% SPIKE in Female Infertility
437% SPIKE in Ovarian Dysfunction
269% SPIKE in Myocardial infarction
291% SPIKE in Bell’s palsy
467% SPIKE in Pulmonary Embolism

Cost benefit by age analysis: The COVID vaccines kill more people than they save for all age groups - Steve Kirsch

Abstract: This paper calculates the risks from taking the vaccine compared to the benefit of being vaccinated (which we assume is a 90% risk reduction) and concludes that the vaccines make no sense for any age group. They kill, in the best case, 2 people for every person saved from COVID. For 20 year olds, we kill 6 people for every person saved. At this point, two separate stopping conditions have been satisfied: 1. The vaccines kill more people than they save 2. The vaccines have killed over 150,000 Americans so far

On 2nd Smartest Guy in the World’s Substack blog, there’s some excellent analysis of Edward Dowd’s charts:

NEW Edward Dowd Analysis: CDC data charts for millennials comparing lowest vaccination rate states vs the highest states

Nanotechnology

While the evidence for this is not concrete, the vaccines may contain undisclosed ingredients, such as graphene oxide, nanoFSM, nanotransducers, et cetera, to facilitate the Internet of Bodies/Mind Control/Smart-Gridding.

DARPA’s N3 program involves the creation of nanotransducers that can bypass the blood-brain barrier and take up residence in the brain. Moderna’s top nanotech experts are linked to DARPA-funded scientists involved in this type of research. There are reports of vaccinated individuals giving off phantom Bluetooth MAC addresses with no known vendor.

Are there undisclosed ingredients in the vaccine? Possibly. There are now multiple independent reports that appear to point in that direction.

• La Quinta Columna: 5G technology, graphene oxide and neuro-rights

• Detection of Graphene in COVID-19 vaccines by Micro-Raman Spectroscopy by Dr. Pablo Campra

• Leading German Chemist Andreas Noack Dies 30 Minutes After Exposing Graphene Oxide, Possibly Assassinated

• UK Citizen 2021 - Case Briefing Document and Lab Report

• Summary of the MAC phenomenon and the intracorporeal network of nanocommunications

• Evidence found to confirm the theory of human body-centered nanonetworks: nano-rectenes

Recent work by Dr. Kevin McCairn and Steve Kirsch and their associates appears to repudiate this. Steve’s team found no phosphorus (which means no genetic material; these were effectively blanks). Kevin’s team confirmed this, but also found contaminants in the form of various metals when they inspected the vials spectroscopically. This highlights the need for continued, up-to-date analysis of these vaccine vials and their contents.

Does the technology exist to do this? Yes, it either already exists, or it soon will. Once you realize the vaccines exist as a pretense to inject people every 6 months with “something”, it stands to reason that the composition may have been intended to be updated over time, as technology improved.

• Nanowire nanocomputer as a finite-state machine - PNAS

• Nanowire probes could drive high-resolution brain-machine interfaces - Elsevier

• HR001118S0029 - DARPA Next-Generation Non-Surgical Neurotechnology (N^3) Proposal - Govtribe

• Wireless and battery-free technologies for neuroengineering

• Dr. James Giordano – From DARPA Mind Weapon Tools, to Nanotechnology | Hacking Our Mind is the Ultimate Agenda

Does the political impetus to do something like this exist? Yes. Look up the WEF’s presentations on transhumanism and the WEF and RAND Corporation’s files on the “Internet of Bodies”. This tech is intended to track people and their movements in Smart Cities, download their health data and biometric data, and analyze their physical and emotional states and predict their future behavior based on that.

• Tracking how our bodies work could change our lives - WEF

• The Internet of Bodies Will Change Everything, for Better or Worse - RAND Corp

But why would they accomplish this with a deadly toxin? Population reduction and human tracking/mind control go hand in hand. People who would otherwise be alarmed at the deaths of their neighbors would have their anxiety reduced by a limbic system hijack, allowing them to be democided without offering any resistance. The tracking measures could be used to take a census of the population and determine precisely how many had died, when, and where.

We are dealing with full-fledged psychopaths.

What This All Means

Let me be quite frank with you. If someone was holding a gun to my head and gave me a choice of this so-called vaccine or a bullet through the brain, I would choose the bullet.

Give me liberty, or give me death. There can be no alternative, no settling for less.

-Spartacus

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