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Some key observations of recent events
S1 NTD Fold/Gal-3 Homology
SARS-CoV-2 Spike S1 subunits have a motif with a close similarity to human Galectin-3. This can activate pathological immune responses. There is a paper from late last year that details these findings entitled The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3, published in Frontiers. I recommend that everyone read it and consider the implications.
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly evolved into a pandemic –the likes of which has not been experienced in 100 years. While novel vaccines show great efficacy, and therapeutics continue to be developed, the persistence of disease, with the concomitant threat of emergent variants, continues to impose massive health and socioeconomic issues worldwide. Studies show that in susceptible individuals, SARS-CoV-2 infection can rapidly progress toward lung injury and acute respiratory distress syndrome (ARDS), with evidence for an underlying dysregulated innate immune response or cytokine release syndrome (CRS). The mechanisms responsible for this CRS remain poorly understood, yet hyper-inflammatory features were also evident with predecessor viruses within the β-coronaviridae family, namely SARS-CoV-1 and the Middle East Respiratory Syndrome (MERS)-CoV. It is further known that the spike protein (S) of SARS-CoV-2 (as first reported for other β-coronaviruses) possesses a so-called galectin-fold within the N-terminal domain of the S1 subunit (S1-NTD). This fold (or pocket) shows structural homology nearly identical to that of human galectin-3 (Gal-3). In this respect, we have recently shown that Gal-3, when associated with epithelial cells or anchored to a solid phase matrix, facilitates the activation of innate immune cells, including basophils, DC, and monocytes. A synthesis of these findings prompted us to test whether segments of the SARS-CoV-2 spike protein might also activate innate immune cells in a manner similar to that observed in our Gal-3 studies. Indeed, by immobilizing S components onto microtiter wells, we show that only the S1 subunit (with the NTD) activates human monocytes to produce a near identical pattern of cytokines as those reported in COVID-19-related CRS. In contrast, both the S1-CTD/RBD, which binds ACE2, and the S2 subunit (stalk), failed to mediate the same effect. Overall, these findings provide evidence that the SARS-CoV-2 spike protein can activate monocytes for cytokines central to COVID-19, thus providing insight into the innate immune mechanisms underlying the CRS and the potential for therapeutic interventions.
What if the presence of this motif pathologically activates immune cells? What if its presence in the S1 NTD of the vaccine-generated Spike leads to loss of self-tolerance of Galectin-3 and its subsequent dysregulation? This could potentially promote autoimmune disease.
These two papers lay out the consequences of Gal-3 dysregulation:
Germinal centers (GC) are important sites for high-affinity and long-lived antibody induction. Tight regulation of GC responses is critical for maintaining self-tolerance. Here, we show that Galectin-3 (Gal-3) is involved in GC development. Compared with WT mice, Gal-3 KO mice have more GC B cells and T follicular helper cells, increased percentages of antibody-secreting cells and higher concentrations of immunoglobulins and IFN-γ in serum, and develop a lupus-like disease. IFN-γ blockade in Gal-3 KO mice reduces spontaneous GC formation, class-switch recombination, autoantibody production and renal pathology, demonstrating that IFN-γ overproduction sustains autoimmunity. The results from chimeric mice show that intrinsic Gal-3 signaling in B cells controls spontaneous GC formation. Taken together, our data provide evidence that Gal-3 acts directly on B cells to regulate GC responses via IFN-γ and implicate the potential of Gal-3 as a therapeutic target in autoimmunity.
Galectin-3 (gal-3) is a β-galactoside-binding lectin, which regulates cell–cell and extracellular interactions during self/non-self-antigen recognition and cellular activation, proliferation, differentiation, migration and apoptosis. It plays a significant role in cellular and tissue pathophysiology by organizing niches that drive inflammation and immune responses. Gal-3 has some therapeutic potential in several diseases, including chronic inflammatory disorders, cancer and autoimmune diseases. Gal-3 exerts a broad spectrum of functions which differs according to its intra- or extracellular localization. Recombinant gal-3 strategy has been used to identify potential mode of action of gal-3; however, exogenous gal-3 may not reproduce the functions of the endogenous gal-3. Notably, gal-3 induces monocyte–macrophage differentiation, interferes with dendritic cell fate decision, regulates apoptosis on T lymphocytes and inhibits B-lymphocyte differentiation into immunoglobulin secreting plasma cells. Considering the influence of these cell populations in the pathogenesis of several autoimmune diseases, gal-3 seems to play a role in development of autoimmunity. Gal-3 has been suggested as a potential therapeutic agent in patients affected with some autoimmune disorders. However, the precise role of gal-3 in driving the inflammatory process in autoimmune or immune-mediated disorders remains elusive. Here, we reviewed the involvement of gal-3 in cellular and tissue events during autoimmune and immune-mediated inflammatory diseases.
Pfizer Vaccine DNA Contamination
Kevin McKernan has found significant evidence of DNA contamination in Pfizer mRNA vaccines. When the contents of the LNPs were sequenced, they were found to contain plasmid DNA with the SV40 promoter sequence, among other things. The DNA contamination was well beyond what one would expect to find in an mRNA vaccine, indicating that Pfizer has basically no quality control at all. Simian Virus 40 contains sequences known to be oncogenic. That is, they promote the formation of tumors.
Dr. Paul Alexander and Anandamide’s Substacks have excellent articles on this contamination:
IgG4 Class Switching
In the past several months, numerous papers have emerged on the phenomenon of IgG4 class switching in repeat COVID-19 vaccination. This is incredibly alarming, for multiple reasons. Jessica Rose on the Unacceptable Jessica blog right here on Substack covered this late last year.
So did Igor Chudov, Adam Gaertner, and DoorlessCarp.
Repeat vaccinations with nucleic acid vaccines provoke immune tolerance. IgG4 neutralizes immune responses and instructs the immune system to ignore the antigen in question.
You don’t want your immune system to tolerate Spike, ever, for obvious reasons (namely, because it’s a nasty structural protein from a coronavirus). Imagine if someone who is Spike-tolerant is exposed to COVID-19. Their immune system will ignore the Spike protein, allowing for enhanced viral replication. The vaccine will, over multiple doses, actually make COVID-19 infections worse.
If anything puts the final nail in the coffin of these vaccines, it would be these findings.
I never thought I’d live to see the day when our own governments would, simultaneously, worldwide, mandate the mass poisoning of billions of people, while also smothering independent voices as “mis-, dis-, and malinformation” and marshaling the enormous resources of intelligence agencies, pharmaceutical companies, and social media providers to reinforce a single, top-down, centralized narrative while suppressing all others.
What they did to us was diabolical. Even here in the US, officials moved in lock-step with the World Health Organization and characterized the rightful exercise of free speech as an “infodemic”, while massively expanding the powers of the already appalling post-PATRIOT Act surveillance state. These actions cost innocent lives.
After navigating 2020 with relative success, young and middle-age healthy people in rich nations began dying in unprecedented numbers in 2021 and 2022. Health authorities haven’t focused enough on this cataclysm of premature death from non-Covid heart attacks, strokes, pulmonary embolisms, kidney failure and cancer.
Hiding these and other realities has become more difficult in the internet age. The information explosion has allowed more people to spot quickly the mistakes of officials and learn the truth. This has changed the relationship between the authorities and those they govern. Those in charge feel threatened.
Are the perpetrators remorseful over this? Not in the least.
Even though I believe I’ve mentioned it before, I highly recommend that people read Aaron Kheriaty’s book, The New Abnormal: The Rise of the Biomedical Security State, because it outlines the exact problems we’re facing in explicit detail. Governments have done an end-run around democratic processes by framing everything in terms of public health. This is really a stroke of evil genius, because basically any political stance can now be deemed unacceptable by the authorities, and then pathologized and turned into a health issue.
Take racism, for instance. Right now, on Cornell University’s CornellHealth page, there is an article that characterizes racism as a public health crisis.
Recent events have once again brought into sharp relief the depth of systemic racism in the U.S., with several high-profile killings of Black Americans at the hands of police officers and the resulting national and international protests. Amid the outrage and pain related to these acts of overt racism and violence, a growing number of local and state government leaders as well as health organizations around the nation are affirming racism as a serious public health crisis. Cornell Health joins those standing with the Black community as well as those advocating for individual civil rights and actively addressing the deep systemic issues that have contributed to the present moment.
Note the usage of collectivizing language, like systemic racism. Racism is an individual disposition. It’s a negative quality of an individual person’s mind. Not liking people of other races is a personal preference, like not liking hot dogs, or not liking balloons. When we characterize personal beliefs and preferences as collective, systemic issues so we can pathologize them as public health crises, we are opening the door for the authorities to be able to adjust and micromanage any and all mental states that a human being can possibly have.
Today, it’s racism. Tomorrow, the authorities will declare public health crises because some people don’t like certain books, or are prejudiced against specific religions. As a matter of fact, any manner of tribal belief that causes friction between two or more groups of people could be declared a public health crisis. It’s very simple. You just say that a certain belief acts as a basis for discrimination against another group—or causes poor mental or physical health outcomes in that group—and that justifies top-down, authoritarian action against that belief. See how this works? The WHO actually has a term for it; the Social Determinants of Health, or SDOH.
The following list provides examples of the social determinants of health, which can influence health equity in positive and negative ways:
Income and social protection
Unemployment and job insecurity
Working life conditions
Housing, basic amenities and the environment
Early childhood development
Social inclusion and non-discrimination
Access to affordable health services of decent quality.
The architects of the New World Order are trying to mold a new man, one who doesn’t create anything out of his own originality and doesn’t have preferences or beliefs that aren’t dictated to him from above. In Friedrich Nietzsche’s Thus Spoke Zarathustra, Zarathustra mentions the Last Man, as the opposite of the Übermensch. A diminished and debased type of human being who takes no risks, strives for nothing, and seeks only security, comfort, and routine. Nietzsche was wrong, however. This is not the Last Man, nor is it the final consequence of nihilism. Far from it. The true Last Man is the Programmable Man; a humanoid, biological robot in the shape of man who doesn’t have any authentic personal beliefs or desires and can be made to consume any idea or product at the whims of the rentier caste.
Today, world leaders seek neuroweapons capable of rewriting people’s political beliefs, creating unrest among the civilian populations of rival powers or suppressing it in one’s own population, and dominating the mind of an adversary without firing a single shot. Right now, various analysts are speaking of China’s Neurostrike capabilities, which they allegedly plan to use in a hypothetical near-future invasion of Taiwan that is looking likelier by the day.
Unknown to many, the Chinese Communist Party (CCP) and its People’s Liberation Army (PLA) have established themselves as world leaders in the development of NeuroStrike weapons. These platforms directly attack, or even control, mammalian brains (including humans) with microwave/directed energy weapons via standalone platforms (i.e., handheld gun) or the broader electromagnetic spectrum. 1 NeuroStrike, as defined by McCreight, refers to the engineered targeting of warfighter and civilian brains using distinct non-kinetic technology to impair cognition, reduce situational awareness, inflict long term neurological degradation and fog normal cognitive functions.2 The CCP views NeuroStrike and psychological warfare as a core component of its asymmetric warfare strategy against the United States and its Allies in the Indo-Pacific
It’s not just China. All of the major powers’ militaries are investigating these technologies and scheming up ways to use them offensively and defensively. In the process, world leaders flaunt the Biological and Toxin Weapons Convention. There is no international regulatory framework that prevents malicious state actors from surreptitiously accessing and affecting people’s minds without their knowledge or consent. If anything, neuroweapons will be placed under the same category as riot agents because of how subtle their effects are.
To quote a passage from Armin Krishnan’s book, “There are strong indicators that controlling large and impoverished populations will become a key challenge in the twenty-first century, as there is a combination of factors that will over time exacerbate already existing problems of overpopulation, resource scarcity, unemployment and failing systems of governance around the world. These problems will be made worse by covert aggression and deliberate destabilization by a variety of state and nonstate actors. The impacts will not be limited to the developing world, although they will be felt most severely there. Western governments seem to be already preparing for mass civil unrest, if not the threat of civil war. For this reason, any technologies and methods that can reduce or otherwise combat political extremism and generally calm populations will be extremely important for the future. There can be little doubt that neuro S/T will play an important role in the homeland security domain, which could make the use of direct force unnecessary.”
If our leaders are defining certain political beliefs as pathologies, and medicalizing them, and seeking out neuro S/T measures to counteract those beliefs, doesn’t this, in essence, mean that we are entering a post-political world? Politics are fundamentally about what competing groups of people want for themselves. They’re about human desires and value judgments. If leaders can simply adjust people’s desires as they see fit, that’s not politics anymore. It’s menticide.
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